Going by the classical definition of T1/2 (time it takes for the compound to reach half of its original concentration), I am finding it difficult to understand the values that winnolin has generated. The data clearly indicates that the levels of both the compounds remain staedy from 0.5hrs to 4hrs. My understanding is that winonlin considers the 3 terminal points (not the one which has zero levels) for the calculation of T1/2. Winnonlin calculated the T1/2 of these compounds as 1.15 and 2.15 hours. My question is about calculation of T1/2 using winonlin with the following set of data:
On at 14:46:00, geeta sharma () sent the message.
PharmPK Discussion List Archive - PK2010056.html - 2010 PharmPK Discussion - Calculation of t 1/2 PharmPK Discussion List Archive Index page
